Le dosi di bicarbonato al 5%, indicate nel metodo Simoncini sono innocue. Le stesse difatti sono utilizzate senza problemi da oltre 30 anni in una miriade di altre situazioni morbose quali:

·        Chetoacidosi diabetica grave. (1)

·        Rianimazione cardiorespiratoria. (2)

·        Gravidanza. (3)

·        Emodialisi. (4)

·        Dialisi peritoneale. (5)

·        Tossicosi farmacologica. (6)

·        Epatopatia. (7)

·        Interventi di chirurgia vascolare. (8)

 

1.    Gamba, G., “Bicarbonate therapy in severe diabetic ketoacidosis. A double blind, randomized, placebo controlled trial. (Rev Invest Clin 1991 Jul-Sep;43(3):234-8).

Miyares Gomez A. in “Diabetic ketoacidosis in childhood: the first day of treatment (An Esp Pediatr 1989 Apr;30(4):279-83).

2.    Levy, M.M., “An evidence-based evaluation of the use of sodium bicarbonate during cardiopulmonary resuscitation” (Crit Care Clin 1998 Jul;14(3):457-83).

Vukmir, R.B., Sodium bicarbonate in cardiac arrest: a reappraisal (Am J Emerg Med 1996 Mar;14(2):192-206).

Bar-Joseph, G., “Clinical use of sodium bicarbonate during cardiopulmonary resuscitation--is it used sensibly?” (Resuscitation 2002 Jul;54(1):47-55).

3.    Zhang. L.,Perhydrit and sodium bicarbonate improve maternal gases and acid-base status during the second stage of labor” Department of Obstetrics and Gynecology, Xiangya Hospital, Hunan Medical University, Changsha 410008.

Maeda, Y., “Perioperative administration of bicarbonated solution to a patient with mitochondrial encephalomyopathy” (Masui 2001 Mar;50(3):299-303).

4.    Avdic. E., “Bicarbonate versus acetate hemodialysis: effects on the acid-base status” (Med Arh 2001;55(4):231-3).

5.    Feriani, M., “Randomized long-term evaluation of bicarbonate-buffered CAPD solution.” (Kidney Int 1998 Nov;54(5):1731-8).

6.    Vrijlandt, P.J., “Sodium bicarbonate infusion for intoxication with tricyclic antidepressives: recommended inspite of lack of scientific evidence” Ned Tijdschr Geneeskd 2001 Sep 1;145(35):1686-9).

Knudsen, K., “Epinephrine and sodium bicarbonate independently and additively increase survival in experimental amitriptyline poisoning.” (Crit Care Med 1997 Apr;25(4):669-74).

7.    Silomon, M., “Effect of sodium bicarbonate infusion on hepatocyte Ca2+ overload during resuscitation from hemorrhagic shock.” (Resuscitation 1998 Apr;37(1):27-32).

Mariano, F., “Insufficient correction of blood bicarbonate levels in biguanide lactic acidosis treated with CVVH and bicarbonate replacement fluids” (Minerva Urol Nefrol 1997 Sep;49(3):133-6).

8.    Dement'eva, I.I., “Calculation of the dose of sodium bicarbonate in the treatment of metabolic acidosis in surgery with and deep hypothermic circulatory arrest” (Anesteziol Reanimatol 1997 Sep-Oct;(5):42-4).